Richard I Morimoto Selected Research

pyrazolone

1/2024	Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis.
8/2015	Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis.
9/2014	Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis.
1/2012	ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.

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Richard I Morimoto Research Topics

Disease

31	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 08/2002
10	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2024 - 10/2005
8	Neoplasms (Cancer) 01/2020 - 04/2004
8	Huntington Disease (Huntington's Disease) 09/2013 - 08/2002
4	Alzheimer Disease (Alzheimer's Disease) 11/2017 - 10/2002
3	Metabolic Diseases (Metabolic Disease) 09/2015 - 06/2008
3	Parkinson Disease (Parkinson's Disease) 03/2013 - 10/2002
2	Cystic Fibrosis (Mucoviscidosis) 01/2020 - 12/2004
2	Thrombosis (Thrombus) 02/2019 - 01/2019
2	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2017 - 10/2002
2	Ataxia (Dyssynergia) 10/2006 - 01/2006
1	Tauopathies 01/2022
1	Epilepsy (Aura) 01/2021
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2021
1	Muscular Diseases (Myopathy) 12/2019
1	Shock 12/2017
1	Amyloid Plaque 11/2017
1	Body Weight (Weight, Body) 11/2015
1	Gliosis 11/2015
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 11/2015
1	Disease Susceptibility (Diathesis) 01/2015
1	Lung Diseases (Lung Disease) 01/2014
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 03/2013
1	Mitochondrial Diseases (Mitochondrial Disease) 05/2007
1	Ischemia 05/2007
1	Heart Injuries 05/2007
1	X-Linked Bulbo-Spinal Atrophy 10/2006
1	Proteostasis Deficiencies 10/2005
1	Amyloidosis 12/2004
1	Dehydration (Water Stress) 05/2004
1	Inborn Genetic Diseases (Disease, Hereditary) 04/2004
1	Carcinogenesis 04/2004

Drug/Important Bio-Agent (IBA)

34	Proteins (Proteins, Gene)FDA Link 01/2024 - 10/2002
9	polyglutamineIBA 11/2015 - 08/2002
7	Superoxide Dismutase-1IBA 08/2015 - 10/2005
5	Molecular Chaperones (Chaperone, Molecular)IBA 01/2020 - 04/2004
4	pyrazoloneIBA 01/2024 - 01/2012
3	Protein AggregatesIBA 12/2019 - 10/2005
2	Protein Isoforms (Isoforms)IBA 01/2022 - 01/2021
2	Metformin (Glucophage)FDA LinkGeneric 02/2019 - 01/2019
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2017 - 04/2004
2	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2017 - 09/2014
1	Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)IBA 01/2021
1	SynucleinsIBA 01/2020
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2020
1	Oncogene Proteins (Oncogene Protein)IBA 01/2020
1	Amyloidogenic ProteinsIBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	Particulate MatterIBA 01/2019
1	CytokinesIBA 01/2019
1	Calcium Release Activated Calcium ChannelsIBA 01/2019
1	tau Proteins (tau Protein)IBA 11/2017
1	Peptides (Polypeptides)IBA 11/2017
1	UbiquitinIBA 11/2017
1	Citalopram FDA LinkGeneric 11/2015
1	Ataxin-3IBA 11/2015
1	PyrazolonesIBA 08/2015
1	SaltsIBA 08/2015
1	Superoxide DismutaseIBA 08/2015
1	AminesIBA 08/2015
1	ClathrinIBA 04/2014
1	AMPA Receptors (AMPA Receptor)IBA 04/2014
1	Ataxin-1IBA 04/2014
1	Prion ProteinsIBA 03/2013
1	CyclohexaneIBA 05/2012
1	Transcription Factors (Transcription Factor)IBA 01/2011
1	Free RadicalsIBA 05/2007
1	Huntingtin ProteinIBA 05/2007
1	Kainic Acid (Kainate)IBA 05/2007
1	Heat Shock Transcription FactorsIBA 04/2006
1	triptolideIBA 04/2006
1	Amyloid beta-PeptidesIBA 02/2006
1	Mutant Proteins (Protein, Mutant)IBA 10/2004
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 05/2004
1	p38 Mitogen-Activated Protein KinasesIBA 05/2004

Therapy/Procedure

2	Therapeutics 01/2024 - 01/2021
1	Pneumonectomy (Lung Volume Reduction) 01/2021